Precision BioSciences’ patent pending Directed Nuclease Editor™ (DNE) enables the rapid production of redesigned homing endonucleases (also known as ‘meganucleases’), capable of producing double-strand breaks at predetermined DNA sites.  The sequence specificity of the designed enzymes is sufficient to define a single cleavage site within a genetic background as large as the human genome.  This break in the DNA effectively marks that spot for user-specified gene modification using the cell’s natural DNA-repair machinery.